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Image Search Results
Journal: bioRxiv
Article Title: A new humanized TCR transgenic mouse model to study citrullinated tenascin C reactive T cells relevant to rheumatoid arthritis
doi: 10.64898/2026.02.12.705563
Figure Lengend Snippet: A) Schematic representation of TNC22 transgenic CD4+CD25– T cell sorting and co-culture with H-2 b or DR4.H-2 b BMDCs. B) Supernatant IL-2 levels secreted by TNC22 transgenic CD4+CD25- T cells when stimulated by H-2 b BMDC or DR4.H-2 b BMDCs. C) Schematic representation of TNC22 CD4+CD25– T cell sorting and transfer into TKO.DR4 recipient mice, followed by immunization and antigen recall. D-F) Supernatant IL2- (D) and IFNγ (E) by splenocytes after antigen recall, or IFNg producing lymph node cells after antigen stimulation in vitro. G-H) Frequencies of TCRβ+ cells (G), CD25+CD4+ T cells and genometric mean (GeoMean) of CD25 (H) in CD4+ T cells from TKO.DR4 recipient mice after antigen recall. One-way ANOVA with Holm-Šídák’s multiple comparison’s test. * - p<0.05, ** - p<0.01 and *** - p<0.001; ns – not significant.
Article Snippet: IFN-γ producing cells were detected using
Techniques: Transgenic Assay, FACS, Co-Culture Assay, In Vitro